CristalloBuild and Guide

Last updated: 07/17/2025

Cristallo is a low-rarity unit who straddles the line between sustain and support.

Most of her kit is supportive. Her first skill [Caged Bird] decreases Reality DEF at rank 2/3 and deals a little damage. Her second skill [Dustless Blossom] grants all allies a small Reality/Mental DEF boost and 1 stack of [Sturdiness], which reduces the next instance of damage they take when attacked.

Her ultimate [This is Radiotherapy] is a mass debuff that inflicts [Nasty Wound] and [Radiation Therapy] on all enemies for 2 rounds. [Radiation Therapy] is a [Neg Status] effect that increases DMG Taken and deals Genesis DMG at the end of the round.

So where is the sustain you were promised? It's actually just her Insight I passive: whenever she gets attacked, Cristallo heals another ally with the lowest HP% for a little HP based on her ATK. She also has some innate DMG Heal.

That's kind of it. Cristallo has an admittedly wide spread of supportive capabilities, but they come with their own complications.

Her Reality DEF shred is quite valuable—[Caged Bird]'s -25% at rank 2 and -35% at rank 3 are better than Bkornblume's -20%/-25%, but remember that this is a pure single-target skill that does nothing at rank 1 except a bit of damage.

The [Sturdiness] and double-DEF buff from [Dustless Blossom] are quite good, and the DEF buff lasts 2 rounds for easy 100% uptime. The only complaint is that the number of [Sturdiness] stacks don't increase with incantation rank; in late-game against enemies who spam mass attacks, 1 stack of [Sturdiness] isn't really enough.

Finally, [Nasty Wound] is just not a very good debuff. Enemy healing only comes up once in a while, and it's either an extremely persistent problem or it doesn't matter. You'll like this the one times you fight the Slime Trianglist, and even then Cristallo won't apply it often enough for it to matter. [Radiation Therapy] is a fun damage-over-time effect with DMG Taken Reduction (you'll still wish you had 100% uptime like Bkornblume, though). The most useful application of Cristallo's ultimate is probably in enabling Blasphemer of Night.

An interesting low-rarity tank-type sustain, Cristallo performs best in low-pressure environments and unfortunately doesn't fare well in late game, where she'll get whittled down or one-shot.